PT  - JOURNAL ARTICLE
AU  - Aye Chan Maung
AU  - Jenny YC Hsieh
AU  - David Carmody
AU  - Swee Du Soon
TI  - Lessons of the month 3: Mosaic Klinefelter syndrome unveiled by acute vertebral fracture in a middle-aged man
AID  - 10.7861/clinmed.2021-0348
DP  - 2021 Jul 01
TA  - Clinical Medicine
PG  - e420--e422
VI  - 21
IP  - 4
4099  - http://www.rcpjournals.org/content/21/4/e420.short
4100  - http://www.rcpjournals.org/content/21/4/e420.full
SO  - Clin Med2021 Jul 01; 21
AB  - Klinefelter syndrome (KS) is the most common sex chromosome disorder in males. It is the result of two or more X chromosomes in a phenotypic male. In addition to primary hypogonadism affecting male sexual development, it is associated with a series of comorbidities such as osteoporosis, psychiatric and cognitive disorders, metabolic syndromes, and autoimmune diseases. A broad spectrum of phenotypes has been described and many cases remain undiagnosed throughout their lifespan. In this case report, we describe a case of mosaic KS unmasked by acute vertebral fracture.