RT Journal Article SR Electronic T1 Safer care for patients with adrenal insufficiency: weighing the evidence, balancing risks and acknowledging uncertainties JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP e541 OP e542 DO 10.7861/clinmed.2021-0528 VO 21 IS 5 A1 Michael Stacey A1 Robert M Gifford A1 David Woods YR 2021 UL http://www.rcpjournals.org/content/21/5/e541.abstract AB The National Patient Safety Alert supporting early recognition and treatment of adrenal crisis is a vital new component of care for adults affected by primary adrenal insufficiency. Benefits for patients with secondary and tertiary adrenal insufficiency need to be weighed alongside other considerations such as security of the diagnosis, relative likelihood of adrenal crisis and potential for anxiety and distress from assigning ‘physical dependency’ in relation to glucocorticoid therapy. All clinicians must be vigilant for and responsive to managing risks of adrenal crisis in at-risk patients, while avoiding diagnostic anchoring in the context of acute illness. More research is required to help define who is at greatest risk of adverse outcomes (including avoidance of therapeutic glucocorticoid therapy for fear of adrenal insufficiency) and a cross-specialty approach is advocated.