PT  - JOURNAL ARTICLE
AU  - Ahmed, Asim
AU  - Alderazi, Sayed A
AU  - Aslam, Rumaisa
AU  - Barkat, Barooq
AU  - Barker, Bethan L
AU  - Bhat, Rahul
AU  - Cassidy, Samuel
AU  - Crowley, Louise E
AU  - Dosanjh, Davinder PS
AU  - Ebrahim, Hussain
AU  - Elndari, Najla
AU  - Gardiner, Claudia
AU  - Gogokhia, Atena
AU  - Grudzinska, Frances S
AU  - Gurung, Megha T
AU  - Hughes, Terry
AU  - Ismail, Iyad
AU  - Iredale, Natasha
AU  - Irshad, Sannaan
AU  - Johnson, Sarah
AU  - Kavanagh, Diana
AU  - Knight, Thomas
AU  - Livesey, Alana
AU  - Lugg, Sebastian T
AU  - Marathe, Manoj
AU  - McDougall, Andrew
AU  - Nawaz, Wasim
AU  - Nettleton, Kimberly
AU  - O’Flynn, Lauren
AU  - Okoth, Kelvin
AU  - Parekh, Dhruv
AU  - Perry, Rita
AU  - Pudney, Elizabeth J
AU  - Sadiq, Ambreen
AU  - Soge, Olutobi
AU  - Soloman, Rhania
AU  - Soltan, Marina
AU  - Strecker, Martin
AU  - Thein, Onn S
AU  - Thickett, David
AU  - Thomas, Ajit
AU  - Thornton, Riah
TI  - Utility of severity assessment tools in COVID-19 pneumonia: a multicentre observational study
AID  - 10.7861/clinmed.2020-1107
DP  - 2022 Jan 01
TA  - Clinical Medicine
PG  - 63--70
VI  - 22
IP  - 1
4099  - http://www.rcpjournals.org/content/22/1/63.short
4100  - http://www.rcpjournals.org/content/22/1/63.full
SO  - Clin Med2022 Jan 01; 22
AB  - Background Severity scores in pneumonia and sepsis are being applied to SARS-CoV-2 infection. We aimed to assess whether these severity scores are accurate predictors of early adverse outcomes in COVID-19.Methods We conducted a multicentre observational study of hospitalised SARS-CoV-2 infection. We assessed risk scores (CURB65, qSOFA, Lac-CURB65, MuLBSTA and NEWS2) in relation to admission to intensive care or death within 7 days of admission, defined as early severe adverse events (ESAE). The 4C Mortality Score was also assessed in a sub-cohort of patients.Findings In 2,387 participants, the overall mortality was 18%. In all scores examined, increasing score was associated with increased risk of ESAE. Area under the curve (AUC) to predict ESAE for CURB65, qSOFA, Lac-CURB65, MuLBSTA and NEWS2 were 0.61, 0.62, 0.59, 0.59 and 0.68, respectively. AUC to predict ESAE was 0.60 with ISARIC 4C Mortality Score.Conclusion None of the scores examined accurately predicted ESAE in SARS-CoV-2 infection. Non-validated scores should not be used to inform clinical decision making in COVID-19.