TY - JOUR T1 - Utility of severity assessment tools in COVID-19 pneumonia: a multicentre observational study JF - Clinical Medicine JO - Clin Med SP - 63 LP - 70 DO - 10.7861/clinmed.2020-1107 VL - 22 IS - 1 AU - Asim Ahmed AU - Sayed A Alderazi AU - Rumaisa Aslam AU - Barooq Barkat AU - Bethan L Barker AU - Rahul Bhat AU - Samuel Cassidy AU - Louise E Crowley AU - Davinder PS Dosanjh AU - Hussain Ebrahim AU - Najla Elndari AU - Claudia Gardiner AU - Atena Gogokhia AU - Frances S Grudzinska AU - Megha T Gurung AU - Terry Hughes AU - Iyad Ismail AU - Natasha Iredale AU - Sannaan Irshad AU - Sarah Johnson AU - Diana Kavanagh AU - Thomas Knight AU - Alana Livesey AU - Sebastian T Lugg AU - Manoj Marathe AU - Andrew McDougall AU - Wasim Nawaz AU - Kimberly Nettleton AU - Lauren O’Flynn AU - Kelvin Okoth AU - Dhruv Parekh AU - Rita Perry AU - Elizabeth J Pudney AU - Ambreen Sadiq AU - Olutobi Soge AU - Rhania Soloman AU - Marina Soltan AU - Martin Strecker AU - Onn S Thein AU - David Thickett AU - Ajit Thomas AU - Riah Thornton Y1 - 2022/01/01 UR - http://www.rcpjournals.org/content/22/1/63.abstract N2 - Background Severity scores in pneumonia and sepsis are being applied to SARS-CoV-2 infection. We aimed to assess whether these severity scores are accurate predictors of early adverse outcomes in COVID-19.Methods We conducted a multicentre observational study of hospitalised SARS-CoV-2 infection. We assessed risk scores (CURB65, qSOFA, Lac-CURB65, MuLBSTA and NEWS2) in relation to admission to intensive care or death within 7 days of admission, defined as early severe adverse events (ESAE). The 4C Mortality Score was also assessed in a sub-cohort of patients.Findings In 2,387 participants, the overall mortality was 18%. In all scores examined, increasing score was associated with increased risk of ESAE. Area under the curve (AUC) to predict ESAE for CURB65, qSOFA, Lac-CURB65, MuLBSTA and NEWS2 were 0.61, 0.62, 0.59, 0.59 and 0.68, respectively. AUC to predict ESAE was 0.60 with ISARIC 4C Mortality Score.Conclusion None of the scores examined accurately predicted ESAE in SARS-CoV-2 infection. Non-validated scores should not be used to inform clinical decision making in COVID-19. ER -