PT  - JOURNAL ARTICLE
AU  - Senanayake Abeysinghe Kularatne
AU  - Chamara Dalugama
TI  - Dengue infection: Global importance, immunopathology and management
AID  - 10.7861/clinmed.2021-0791
DP  - 2022 Jan 01
TA  - Clinical Medicine
PG  - 9--13
VI  - 22
IP  - 1
4099  - http://www.rcpjournals.org/content/22/1/9.short
4100  - http://www.rcpjournals.org/content/22/1/9.full
SO  - Clin Med2022 Jan 01; 22
AB  - Dengue is an arboviral infection that is hyperendemic in tropical and subtropical climates. Clinical manifestations of dengue can range from asymptomatic infection to severe infection with multi-organ failure. Dengue haemorrhagic fever (DHF) is a subcategory in dengue infection with a hallmark of plasma leak (ie critical phase). The plasma leak in DHF is selective (pleuroperitoneal spaces), transient and dynamic, and needs careful monitoring and meticulous fluid resuscitation. In addition, dengue fever may present with extended and unusual manifestations affecting any organ, including the heart, liver, kidney and brain. Studies on vaccine development and vector control are ongoing to prevent this infection of global importance. In this article, the clinicopathological features and management aspects of dengue are discussed.