RT Journal Article
SR Electronic
T1 Dengue infection: Global importance, immunopathology and management
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 9
OP 13
DO 10.7861/clinmed.2021-0791
VO 22
IS 1
A1 Kularatne, Senanayake Abeysinghe
A1 Dalugama, Chamara
YR 2022
UL http://www.rcpjournals.org/content/22/1/9.abstract
AB Dengue is an arboviral infection that is hyperendemic in tropical and subtropical climates. Clinical manifestations of dengue can range from asymptomatic infection to severe infection with multi-organ failure. Dengue haemorrhagic fever (DHF) is a subcategory in dengue infection with a hallmark of plasma leak (ie critical phase). The plasma leak in DHF is selective (pleuroperitoneal spaces), transient and dynamic, and needs careful monitoring and meticulous fluid resuscitation. In addition, dengue fever may present with extended and unusual manifestations affecting any organ, including the heart, liver, kidney and brain. Studies on vaccine development and vector control are ongoing to prevent this infection of global importance. In this article, the clinicopathological features and management aspects of dengue are discussed.