RT Journal Article
SR Electronic
T1 Lessons of the month 2: A case of inappropriate drug–drug interaction in kidney transplant
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 169
OP 171
DO 10.7861/clinmed.2021-0789
VO 22
IS 2
A1 Min-Hui Tan
A1 Seow-Yeing Yee
A1 Rosnawati Yahya
YR 2022
UL http://www.rcpjournals.org/content/22/2/169.abstract
AB Carbamazepine remains a first-line antiepileptic medication for the treatment of partial seizures. Despite its widespread use, carbamazepine has significant neurotoxicity and hypersensitivity reactions. We report a case of a patient post-kidney transplant who was on regular carbamazepine for childhood epilepsy and developed nystagmus, diplopia and a broad-base gait after receiving diltiazem. Understanding of the interaction between diltiazem and carbamazepine is necessary to prevent the neurotoxic effects.