PT  - JOURNAL ARTICLE
AU  - Doriella Camilleri
AU  - Anthony Fiorini
TI  - Lessons of the month 2: Olanzapine-induced hypothermia and hand oedema
AID  - 10.7861/clinmed.2022-0113
DP  - 2022 May 01
TA  - Clinical Medicine
PG  - 285--286
VI  - 22
IP  - 3
4099  - http://www.rcpjournals.org/content/22/3/285.short
4100  - http://www.rcpjournals.org/content/22/3/285.full
SO  - Clin Med2022 May 01; 22
AB  - Introduction We describe a case of olanzapine-induced hypothermia and hand oedema in an older adult with behavioural and psychological symptoms of dementia (BPSD).Case presentation An 82-year-old woman with hypothyroidism and dementia was reviewed by the geriatric team at a nursing home in view of lethargy and an unrecordable oral temperature. She was noted to have a bilateral hand oedema and right basal crackles. Investigations revealed high white cell count and inflammatory markers. She was treated as per hypothermia and communityacquired pneumonia protocols. The patient did not have the expected response to treatment. Olanzapine was tailed down and stopped with good effect as it was suspected to be a contributory cause to both the hypothermia and oedema.Discussion and conclusion Potentially inappropriate polypharmacy can be specifically targeted with effective deprescribing. Treatment review should be encouraged on a regular basis, especially in frail older adults with polypharmacy.