PT  - JOURNAL ARTICLE
AU  - Emma Conway O'Brien
AU  - Sahla Ali
AU  - Timothy Chevassut
TI  - Sickle cell disease: an update
AID  - 10.7861/clinmed.2022-0143
DP  - 2022 May 01
TA  - Clinical Medicine
PG  - 218--220
VI  - 22
IP  - 3
4099  - http://www.rcpjournals.org/content/22/3/218.short
4100  - http://www.rcpjournals.org/content/22/3/218.full
SO  - Clin Med2022 May 01; 22
AB  - Sickle cell disease is a common inherited disorder that is characterised by chronic haemolysis and vaso-occlusive episodes, resulting in severe pain and end-organ damage. The most frequent acute manifestation of sickle cell disease is a painful vaso-occlusive crisis, which can, in some cases, develop into a sickle chest crisis: a life-threatening complication of sickle cell disease that requires early recognition and prompt intervention to prevent progressive respiratory failure. In addition to the acute complications, patients with sickle cell disease are also at risk of a number of chronic complications that require multidisciplinary specialist input.