RT Journal Article
SR Electronic
T1 Sickle cell disease: an update
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 218
OP 220
DO 10.7861/clinmed.2022-0143
VO 22
IS 3
A1 Emma Conway O'Brien
A1 Sahla Ali
A1 Timothy Chevassut
YR 2022
UL http://www.rcpjournals.org/content/22/3/218.abstract
AB Sickle cell disease is a common inherited disorder that is characterised by chronic haemolysis and vaso-occlusive episodes, resulting in severe pain and end-organ damage. The most frequent acute manifestation of sickle cell disease is a painful vaso-occlusive crisis, which can, in some cases, develop into a sickle chest crisis: a life-threatening complication of sickle cell disease that requires early recognition and prompt intervention to prevent progressive respiratory failure. In addition to the acute complications, patients with sickle cell disease are also at risk of a number of chronic complications that require multidisciplinary specialist input.