PT  - JOURNAL ARTICLE
AU  - Steve Bloom
AU  - Katie Wynne
AU  - Owais Chaudhri
TI  - Gut feeling – the secret of satiety?
AID  - 10.7861/clinmedicine.5-2-147
DP  - 2005 Mar 01
TA  - Clinical Medicine
PG  - 147--152
VI  - 5
IP  - 2
4099  - http://www.rcpjournals.org/content/5/2/147.short
4100  - http://www.rcpjournals.org/content/5/2/147.full
SO  - Clin Med2005 Mar 01; 5
AB  - The worsening global epidemic of obesity has increased the urgency of research aimed at understanding the mechanisms of appetite regulation. An important aspect of the complex pathways involved in modulating energy intake is the interaction between hormonal signals of energy status released from the gut in response to a meal, and appetite centres in the brain and brainstem. In particular, the gut peptides cholecystokinin, peptide YY, glucagonlike peptide 1, oxyntomodulin and pancreatic polypeptide have been implicated in signaling satiety post-prandially. The ultimate goal of work in this field is the development of effective treatments for obesity, and manipulation of these gut–brain axes offers potentially useful strategies for the conquest of this significant cause of morbidity and mortality and future burden on healthcare systems worldwide.