TY - JOUR T1 - Failure to mount a humoral response to COVID-19 vaccination identifies individuals with previously undiagnosed severe antibody deficiency state: preliminary data from the COVID-19 ENLIST study JF - Future Healthcare Journal JO - Future Healthc J SP - 25 LP - 26 DO - 10.7861/fhj.9-2-s25 VL - 9 IS - Suppl 2 AU - Mark Ponsford Y1 - 2022/07/01 UR - http://www.rcpjournals.org/content/9/Suppl_2/25.abstract N2 - Immunisation with mRNA or adenovirus-based COVID-19 vaccinations provides a potent immunogenic stimulus. In the vast majority of individuals, vaccination elicits cellular and humoral (antibody) immune responses to the spike protein mediating protection against severe disease against SARS-CoV-2 infection, including novel variants.1 However, susceptibility to severe disease and failure to respond to COVID-19 vaccinations remain a particular concern in immunocompromised patient groups.2 In a recent survey of vaccine responses in individuals with inherited and acquired forms of immunodeficiency, the magnitude of the humoral IgG vaccine response to COVID-19 vaccines appeared related to the magnitude and nature of the underlying immunodeficiency.2 Here, … ER -