RT Journal Article
SR Electronic
T1 Cancer immunotherapy and the management of side effects
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 56
OP 60
DO 10.7861/clinmed.2022-0589
VO 23
IS 1
A1 Preethika Mahalingam
A1 Thomas Newsom-Davis
YR 2023
UL http://www.rcpjournals.org/content/23/1/56.abstract
AB The use of cancer immunotherapies such as immune checkpoint inhibitors (ICIs) has been a paradigm shift in harnessing the immune system to act against cancer cells, and transformed the treatment of several solid and haematological malignancies. Cancer immunotherapies have a unique toxicity profile dependent on their mechanism of action, related to upregulation of immune activity. These can be severe and lead to life-threatening organ toxicity, and therefore identification of at-risk patient groups, early detection and prompt initiation of steroids and other immune-modulating agents is imperative. Acute presentations with toxicity related to these agents comprise a significant proportion of primary and secondary care presentations related to treatment toxicity in oncology. This article will focus on the diagnosis and management of common toxicities associated with immune checkpoint inhibitors, the most commonly utilised cancer immunotherapies.