RT Journal Article SR Electronic T1 Why medical research needs a new specialty of ‘pure medical science’ JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 163 OP 165 DO 10.7861/clinmedicine.6-2-163 VO 6 IS 2 A1 Bruce G Charlton YR 2006 UL http://www.rcpjournals.org/content/6/2/163.abstract AB Sciences tend to go through boom and bust phases. Following decades of rapid expansion, medical science is now due for a collapse in overall funding. Furthermore, there has been a decline in the rate of therapeutic innovation, with fewer significant breakthroughs and little progress in several major areas of medicine such as oncology, psychiatry and autoimmune disorders. Mainstream medical research has gradually evolved into a form similar to industrial research and development (R&D), aiming at steady, reliable, predictable progress by ringing minor variations on existing approaches. Where this risk-averse approach is failing, a more speculative strategy is indicated. A new research specialty of ‘pure medical science’ would aim to seek radical new theories, technologies and therapies, and subject these to professional evaluation to the point where they can be applied in practice by more mainstream ‘applied’ medical scientists. A specialty of ‘pure medical science’ might be launched by financial support from patrons who wish to be associated with an elite new medical research discipline.