RT Journal Article
SR Electronic
T1 Frontline antibiotic therapy
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 263
OP 268
DO 10.7861/clinmedicine.13-3-263
VO 13
IS 3
A1 Alasdair MacGowan
A1 Maha Albur
YR 2013
UL http://www.rcpjournals.org/content/13/3/263.abstract
AB The need to use front-line antibiotics wisely has never been greater. Antibiotic resistance and multi-drug resistant infection, driven by antibiotic use, remain major public health and professional concerns. To overcome these infection problems, use of older antibiotics active against multi drug-resistant pathogens is increasing – for example, colistin, fosfomycin, pivmecillinam, pristinamycin, temocillin and oral tetracyclines. The number of new antibacterials reaching clinical practice has reduced significantly in the last 20 years, most being focused on therapy of Gram-positive infection – eg linezolid, daptomycin, telavancin and ceftaroline. Recent guidance on antibiotic stewardship in NHS trusts in England is likely to provide a backdrop to antibiotic use in hospitals in the next 5 years.