@article {G{\"u}nther279, author = {Gunar G{\"u}nther}, title = {Multidrug-resistant and extensively drug-resistant tuberculosis: a review of current concepts and future challenges}, volume = {14}, number = {3}, pages = {279--285}, year = {2014}, doi = {10.7861/clinmedicine.14-3-279}, publisher = {Royal College of Physicians}, abstract = {Multidrug-resistant and extensively drug-resistant tuberculosis are recent global health issues, which makes tuberculosis {\textendash} after the success of short course treatment during the second half of the last century {\textendash} a major health challenge. Globalisation, health inequalities, competing economic interests and political instability contribute substantially to the spread of drug-resistant strains, which are associated with high rates of morbidity and mortality. Issues such as increasing transmission of drug-resistant strains, poor diagnostic coverage and a lengthy, toxic treatment need to be overcome by innovative approaches to tuberculosis control, prevention, diagnostics and treatment. This review addresses recent developments and future concepts.}, issn = {1470-2118}, URL = {https://www.rcpjournals.org/content/14/3/279}, eprint = {https://www.rcpjournals.org/content/14/3/279.full.pdf}, journal = {Clinical Medicine} }