TY - JOUR T1 - Multidrug-resistant and extensively drug-resistant tuberculosis: a review of current concepts and future challenges JF - Clinical Medicine JO - Clin Med SP - 279 LP - 285 DO - 10.7861/clinmedicine.14-3-279 VL - 14 IS - 3 AU - Gunar Günther Y1 - 2014/06/01 UR - http://www.rcpjournals.org/content/14/3/279.abstract N2 - Multidrug-resistant and extensively drug-resistant tuberculosis are recent global health issues, which makes tuberculosis – after the success of short course treatment during the second half of the last century – a major health challenge. Globalisation, health inequalities, competing economic interests and political instability contribute substantially to the spread of drug-resistant strains, which are associated with high rates of morbidity and mortality. Issues such as increasing transmission of drug-resistant strains, poor diagnostic coverage and a lengthy, toxic treatment need to be overcome by innovative approaches to tuberculosis control, prevention, diagnostics and treatment. This review addresses recent developments and future concepts. ER -