PT  - JOURNAL ARTICLE
AU  - Gunar Günther
TI  - Multidrug-resistant and extensively drug-resistant tuberculosis: a review of current concepts and future challenges
AID  - 10.7861/clinmedicine.14-3-279
DP  - 2014 Jun 01
TA  - Clinical Medicine
PG  - 279--285
VI  - 14
IP  - 3
4099  - http://www.rcpjournals.org/content/14/3/279.short
4100  - http://www.rcpjournals.org/content/14/3/279.full
SO  - Clin Med2014 Jun 01; 14
AB  - Multidrug-resistant and extensively drug-resistant tuberculosis are recent global health issues, which makes tuberculosis – after the success of short course treatment during the second half of the last century – a major health challenge. Globalisation, health inequalities, competing economic interests and political instability contribute substantially to the spread of drug-resistant strains, which are associated with high rates of morbidity and mortality. Issues such as increasing transmission of drug-resistant strains, poor diagnostic coverage and a lengthy, toxic treatment need to be overcome by innovative approaches to tuberculosis control, prevention, diagnostics and treatment. This review addresses recent developments and future concepts.