RT Journal Article
SR Electronic
T1 Multidrug-resistant and extensively drug-resistant tuberculosis: a review of current concepts and future challenges
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 279
OP 285
DO 10.7861/clinmedicine.14-3-279
VO 14
IS 3
A1 Gunar Günther
YR 2014
UL http://www.rcpjournals.org/content/14/3/279.abstract
AB Multidrug-resistant and extensively drug-resistant tuberculosis are recent global health issues, which makes tuberculosis – after the success of short course treatment during the second half of the last century – a major health challenge. Globalisation, health inequalities, competing economic interests and political instability contribute substantially to the spread of drug-resistant strains, which are associated with high rates of morbidity and mortality. Issues such as increasing transmission of drug-resistant strains, poor diagnostic coverage and a lengthy, toxic treatment need to be overcome by innovative approaches to tuberculosis control, prevention, diagnostics and treatment. This review addresses recent developments and future concepts.