TY - JOUR T1 - Botulinum toxin in the management of spasticity in adults JF - Clinical Medicine JO - Clin Med SP - 128 LP - 130 DO - 10.7861/clinmedicine.2-2-128 VL - 2 IS - 2 AU - Lynne Turner-Stokes AU - Anthony Ward Y1 - 2002/03/01 UR - http://www.rcpjournals.org/content/2/2/128.abstract N2 - Botulinum toxin (BTX) is a powerful neurotoxin which blocks cholinergic transmission at the neuromuscular junction. Judiciously applied, it can reduce local muscle overactivity while maintaining the strength in other muscles. To date BTX has not been licensed for use in spasticity in the UK and the literature pertaining to clinical practice is still relatively scant. However, controlled trials have provided evidence of the effectiveness of BTX both in reducing spasticity itself and in achieving functional gain. The guidance given here to clinicians involved in the management of spasticity covers the types of patient suitable for treatment using BTX, the appropriate dosage, and the necessary follow-up procedures and documentation. ER -