%0 Journal Article %A Esha Abrol %A Cristina González-Pulido %A Juan M Praena-Fernández %A David A Isenberg %T A retrospective study of long-term outcomes in 152 patients with primary Sjögren's syndrome: 25-year experience %D 2014 %R 10.7861/clinmedicine.14-2-157 %J Clinical Medicine %P 157-164 %V 14 %N 2 %X The objective of this study was to evaluate the 25-year outcome of patients with primary Sjögren's syndrome (pSS). One hundred and fifty-two patients diagnosed with pSS (American–European classification criteria) were retrospectively and descriptively analysed (1986–2011). Of all 152 patients, 55.9% were alive, 18.4% had died and 25.7% discontinued follow-up (mostly due to old age). Malignancy affected 28.3% and non-Hodgkin's lymphoma (NHL) affected 10.5%. The adjusted risk for development of NHL was an odds ratio (OR) of 10.5 (95% confidence interval [CI]: 3.05–36.42) in patients with vasculitis (p<0.001), and OR 3.4 (95% CI 1.05–11.2) in the presence of glandular complications (parotid swelling, lymphadenopathy) (p < 0.041). Seventy-five patients (49.3%) developed other autoimmune diseases (autoimmune thyroid disease [15.8%], pulmonary fibrosis [7.2%] and vasculitis [10.5%]). Although the course of pSS is relatively benign, over 25 years patients experience more clinical complications than previously described. In addition, vasculitis and glandular manifestations were significant predictors for NHL. %U https://www.rcpjournals.org/content/clinmedicine/14/2/157.full.pdf