PT - JOURNAL ARTICLE AU - Claire N Harrison AU - Mary F McMullin TI - Update in the myeloproliferative neoplasms AID - 10.7861/clinmedicine.14-6-s66 DP - 2014 Dec 01 TA - Clinical Medicine PG - s66--s70 VI - 14 IP - Suppl 6 4099 - http://www.rcpjournals.org/content/14/Suppl_6/s66.short 4100 - http://www.rcpjournals.org/content/14/Suppl_6/s66.full SO - Clin Med2014 Dec 01; 14 AB - The differential diagnosis of haematological abnormalities, such as leucocytosis, erythocytosis, thrombocytosis or indeed anaemia, is wide and disarming. Here we report on significant updates in the differential diagnosis of erythrocyosis and thrombocytosis presenting a simplified schema for the clinician. We then move to discuss significant advances in this field which have followed a series of key molecular findings, most specifically those affecting the JAK/STAT pathway.