TY - JOUR T1 - Dyslipidaemia: what's around the corner? JF - Clinical Medicine JO - Clin Med SP - s41 LP - s44 DO - 10.7861/clinmedicine.14-6-s41 VL - 14 IS - Suppl 6 AU - Anthony S Wierzbicki AU - Dilinika Perera AU - Mfon Ewang-Emukowhate Y1 - 2014/12/01 UR - http://www.rcpjournals.org/content/14/Suppl_6/s41.abstract N2 - Hyperlipidaemia is a major risk factor for the development of atherosclerosis and cardiovascular disease. Statins are the mainstay of therapy and new guidelines focus on the use of these agents without specific targets for low-density lipoprotein (LDL)-cholesterol or non high-density lipoprotein (HDL)-cholesterol. However, patients remain at risk of cardiovascular disease despite statin therapy so new drugs are required. This article reviews therapies in development to further lower LDL-cholesterol (Proprotein convertase subtilisin/kexin-9 (PCSK-9) inhibitors), raise HDL-holesterol (cholesterol ester transfer protein inhibitors (CETPIs)) and reduce triglycerides (novel peroxisome proliferator-activated receptor (PPAR)-agonists and omega-3 fatty acid preparations). Specialised therapies are in development for treatment of orphan disoders such as homozygous familial hypercholesterolaemia (lomitapide) or familial chylomicroaemia (alipogene tiparvovec). These novel lipid-lowering agents are likely to find uses in treating patients at the highest cardiovascular risk. ER -