PT - JOURNAL ARTICLE AU - William Owen Pickrell AU - Phil EM Smith TI - Treatment of resistant epilepsy AID - 10.7861/clinmedicine.14-6-s1 DP - 2014 Dec 01 TA - Clinical Medicine PG - s1--s6 VI - 14 IP - Suppl 6 4099 - http://www.rcpjournals.org/content/14/Suppl_6/s1.short 4100 - http://www.rcpjournals.org/content/14/Suppl_6/s1.full SO - Clin Med2014 Dec 01; 14 AB - Treatment resistance affects around 20% of people with epilepsy and carries a significant comorbidity. It is important to ensure that the diagnosis of epilepsy is secure and the underlying cause of the epilepsy is investigated thoroughly. Management involves early referral for epilepsy surgery when suitable, optimisation of pharmacological treatment, and consideration of comorbidities such as depression.