RT Journal Article SR Electronic T1 Treatment of resistant epilepsy JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP s1 OP s6 DO 10.7861/clinmedicine.14-6-s1 VO 14 IS Suppl 6 A1 William Owen Pickrell A1 Phil EM Smith YR 2014 UL http://www.rcpjournals.org/content/14/Suppl_6/s1.abstract AB Treatment resistance affects around 20% of people with epilepsy and carries a significant comorbidity. It is important to ensure that the diagnosis of epilepsy is secure and the underlying cause of the epilepsy is investigated thoroughly. Management involves early referral for epilepsy surgery when suitable, optimisation of pharmacological treatment, and consideration of comorbidities such as depression.