PT  - JOURNAL ARTICLE
AU  - Crispin T Hiley
AU  - Charles Swanton
TI  - Spatial and temporal cancer evolution: causes and consequences of tumour diversity
AID  - 10.7861/clinmedicine.14-6-s33
DP  - 2014 Dec 01
TA  - Clinical Medicine
PG  - s33--s37
VI  - 14
IP  - Suppl 6
4099  - http://www.rcpjournals.org/content/14/Suppl_6/s33.short
4100  - http://www.rcpjournals.org/content/14/Suppl_6/s33.full
SO  - Clin Med2014 Dec 01; 14
AB  - Our knowledge of the morphological heterogeneity of cancer has recently been augmented by the genomic heterogeneity revealed by the use of next-generation sequencing technology. We now know that no two cancers are alike and that even different regions within the same tumour vary in their composition. Tumours consist of multiple clonal populations and they evolve under Darwinian principles. This review summarizes some of the causes of such diversity and its implication for cancer management.