RT Journal Article
SR Electronic
T1 Optimising long-term graft survival: establishing the benefit of targeting B lymphocytes
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP s84
OP s88
DO 10.7861/clinmedicine.14-6-s84
VO 14
IS Suppl 6
A1 Kin Yee Shiu
A1 Anthony Dorling
YR 2014
UL http://www.rcpjournals.org/content/14/Suppl_6/s84.abstract
AB Kidney transplants do not last for the natural lifespan of most recipients. Of the reasons why transplants fail, damage by the immune system is the commonest cause. Understanding how the immune system recognises transplanted organs has increased significantly in recent years, but there is little insight into how organs are damaged, and no still no way of suppressing immune-mediated damage without exposing patients to the detrimental effects of long-term immunosuppression. In this article, we review the role of antibodies and B cells in immune-mediated damage of kidney transplants, and discuss the potential for manipulation of B cells to improve clinical outcomes.