PT  - JOURNAL ARTICLE
AU  - Jonathan R Lambourne
AU  - Tim Brooks
TI  - &lt;em&gt;Brucella&lt;/em&gt; and &lt;em&gt;Coxiella&lt;/em&gt;; if you don&#039;t look, you don&#039;t find
AID  - 10.7861/clinmedicine.15-1-91
DP  - 2015 Feb 01
TA  - Clinical Medicine
PG  - 91--92
VI  - 15
IP  - 1
4099  - http://www.rcpjournals.org/content/15/1/91.short
4100  - http://www.rcpjournals.org/content/15/1/91.full
SO  - Clin Med2015 Feb 01; 15
AB  - Brucella and Coxiella are similar; both are obligate intracellular, zoonotic pathogens with a broad geographic distribution. Infection in animals is usually asymptomatic, but causes fetal loss and therefore has significant economic impact. Human infection may be asymptomatic or give rise to either organ-specific or multi-system disease. Organism culture is challenging for Coxiella and can lack sensitivity for Brucella. Therefore, infection is most commonly diagnosed by serology, but this may be negative in early infection and serology results may be challenging to interpret. Both Brucella and Coxiella are typically susceptible to a wide range of antimicrobials, but long courses may be needed.