RT Journal Article
SR Electronic
T1 <em>Brucella</em> and <em>Coxiella</em>; if you don't look, you don't find
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 91
OP 92
DO 10.7861/clinmedicine.15-1-91
VO 15
IS 1
A1 Jonathan R Lambourne
A1 Tim Brooks
YR 2015
UL http://www.rcpjournals.org/content/15/1/91.abstract
AB Brucella and Coxiella are similar; both are obligate intracellular, zoonotic pathogens with a broad geographic distribution. Infection in animals is usually asymptomatic, but causes fetal loss and therefore has significant economic impact. Human infection may be asymptomatic or give rise to either organ-specific or multi-system disease. Organism culture is challenging for Coxiella and can lack sensitivity for Brucella. Therefore, infection is most commonly diagnosed by serology, but this may be negative in early infection and serology results may be challenging to interpret. Both Brucella and Coxiella are typically susceptible to a wide range of antimicrobials, but long courses may be needed.