PT - JOURNAL ARTICLE AU - Nwe Ni Than AU - Philip N Newsome TI - Non-alcoholic fatty liver disease: when to intervene and with what AID - 10.7861/clinmedicine.15-2-186 DP - 2015 Apr 01 TA - Clinical Medicine PG - 186--190 VI - 15 IP - 2 4099 - http://www.rcpjournals.org/content/15/2/186.short 4100 - http://www.rcpjournals.org/content/15/2/186.full SO - Clin Med2015 Apr 01; 15 AB - Non-alcoholic fatty liver disease (NAFLD) is increasingly common due to the rising prevalence of obesity in both children and adults. It is associated with metabolic risk factors such as diabetes mellitus, dyslipidaemia and hypertension, and is associated with increased mortality both from cardiovascular-related and liver-related deaths. Identification of those individuals with significant inflammation and fibrosis is a critical part of the patient pathway. Current treatments for NAFLD include weight loss from lifestyle modification or bariatric surgery, management of underlying metabolic risk factors and for those with end stage liver disease, liver transplantation.