RT Journal Article SR Electronic T1 Drug therapy in headache JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 273 OP 279 DO 10.7861/clinmedicine.15-3-273 VO 15 IS 3 A1 Mark W Weatherall YR 2015 UL http://www.rcpjournals.org/content/15/3/273.abstract AB All physicians will encounter patients with headaches. Primary headache disorders are common, and often disabling. This paper reviews the principles of drug therapy in headache in adults, focusing on the three commonest disorders presenting in both primary and secondary care: tension-type headache, migraine and cluster headache. The clinical evidence on the basis of which choices can be made between the currently available drug therapies for acute and preventive treatment of these disorders is presented, and information given on the options available for the emergency parenteral treatment of refractory migraine attacks and cluster headache.