RT Journal Article
SR Electronic
T1 Lesson of the month 1: Acute flecainide overdose and the potential utility of lipid emulsion therapy
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 301
OP 303
DO 10.7861/clinmedicine.15-3-301
VO 15
IS 3
A1 Omar Mukhtar
A1 John RH Archer
A1 Paul I Dargan
A1 David M Wood
YR 2015
UL http://www.rcpjournals.org/content/15/3/301.abstract
AB Lipid-emulsion therapy (Intralipid®) has been advocated as a potential treatment for the management of cardio-toxicity arising from lipid-soluble drugs, particularly those acting upon sodium channels. This, on the basis of a number of ex vivo studies and animal models, suggests that partitioning a drug into lipid could alter its pharmacokinetics and result in significant clinical improvements. Its subsequent use in clinical case series has been seen as confirmation of this mechanism of action. While there are undoubtedly instances where lipid emulsion therapy has been associated with a desirable outcome in humans, as described in this case report, clinicians are reminded that they should not attribute causality, on this basis alone.