TY - JOUR T1 - Vitamin D – what is normal according to latest research and how should we deal with it? JF - Clinical Medicine JO - Clin Med SP - 171 LP - 174 DO - 10.7861/clinmedicine.16-2-171 VL - 16 IS - 2 AU - Neil JL Gittoes Y1 - 2016/04/01 UR - http://www.rcpjournals.org/content/16/2/171.abstract N2 - Vitamin D deficiency is a public health concern. Mediated by classical endocrine effects, vitamin D deficiency is causally linked with bone and calcium disorders. Non-endocrine actions of vitamin D are also widely recognised and these effects are mediated by local tissue activation of vitamin D bringing about intracrine effects in non-classical sites. Supported by large volumes of observational studies linking low circulating vitamin D with negative outcomes for many common disease states, there is growing interest that vitamin D may be central to the pathology and outcomes of many common diseases, including cardiovascular, cancer and autoimmune conditions. This article explores the quality of evidence linking vitamin D and various disease outcomes, and furthermore describes some of the cellular and molecular mechanisms of vitamin D action that may help explain some of the incongruity of data observed in observational versus interventional studies of vitamin D supplementation. ER -