PT - JOURNAL ARTICLE AU - Farai Nyatsanza AU - Craig Tipple TI - Syphilis: presentations in general medicine AID - 10.7861/clinmedicine.16-2-184 DP - 2016 Apr 01 TA - Clinical Medicine PG - 184--188 VI - 16 IP - 2 4099 - http://www.rcpjournals.org/content/16/2/184.short 4100 - http://www.rcpjournals.org/content/16/2/184.full SO - Clin Med2016 Apr 01; 16 AB - Syphilis is caused by the spirochete bacterium Treponema pallidum and can be transmitted both sexually and from mother to child. T pallidum can infect any organ and produces a clinical disease with a relapsing and remitting course. It is not hard to see, therefore, why it is often described as the great mimic. In this review, we provide an update of modern syphilis epidemiology, clinical presentations, and testing and treatment strategies.