RT Journal Article
SR Electronic
T1 An in vitro analysis of the effect of acidosis on coagulation in chronic disease states – a thromboelastograph study
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 230
OP 234
DO 10.7861/clinmedicine.16-3-230
VO 16
IS 3
A1 Hayden White
A1 Robert Bird
A1 Kellie Sosnowski
A1 Mark Jones
YR 2016
UL http://www.rcpjournals.org/content/16/3/230.abstract
AB Thrombosis is a complication of many chronic illnesses. Chronic obstructive pulmonary disease (COPD) and diabetes mellitus are common medical conditions frequently associated with a hypercoagulable state. Acidaemia has been shown to reduce coagulation. COPD and diabetes mellitus during acute deterioration can present with a severe acidaemia. The impact of this acidaemia on coagulation is poorly studied. Patients presenting with a diagnosis of diabetic ketoacidosis or type II respiratory failure from COPD and a pH of less than 7.2 were included in our study. A coagulation screen and a thromboelastograph (TEG) were performed on admission and 24 hours later. The mean pH on admission was 7.07 and mean base excess was –16.3. The activated partial thromboplastin time was associated with pH change but remained within the normal range (26–41 s). All other coagulation and TEG parameters failed to show evidence of association (p>0.05). In the two models of non-haemorrhagic acidosis investigated, coagulation was not altered by the changes in pH. More work is needed to understand the complex relationship between factors affecting coagulation in individual disease processes.