RT Journal Article SR Electronic T1 An update on hepatitis C virus JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP s33 OP s36 DO 10.7861/clinmedicine.15-6-s33 VO 15 IS Suppl 6 A1 Paul Klenerman A1 Karen Fitzmaurice YR 2015 UL http://www.rcpjournals.org/content/15/Suppl_6/s33.abstract AB Chronic hepatitis caused by hepatitis C virus infection is one of the leading causes of liver cirrhosis and hepatocellular carcinoma globally. Over the last few years, there have been significant advances in our understanding of the immunopathogenesis of this infection, as well as revolutionary developments in the therapeutic armamentarium. The introduction of a number of new oral antiviral agents is already delivering major benefits to patients as they are generally well tolerated and are associated with excellent response rates in the majority. Nonetheless, a number of clinical scenarios remain challenging and research is ongoing in these areas. In this update, we review developments in both basic as well as translational research in the field.