RT Journal Article
SR Electronic
T1 Epigenetic mechanisms and drug discovery in rheumatology
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP s64
OP s71
DO 10.7861/clinmedicine.15-6-s64
VO 15
IS Suppl 6
A1 David F Tough
A1 Rab K Prinjha
A1 Paul P Tak
YR 2015
UL http://www.rcpjournals.org/content/15/Suppl_6/s64.abstract
AB There is a growing understanding of the epigenetic mechanisms that regulate gene expression in healthy conditions and a realisation that dysregulation of these mechanisms is an underlying factor in many human diseases. We discuss studies demonstrating that small molecule inhibitors of epigenetic regulatory proteins can block pathogenic mechanisms associated with rheumatoid arthritis, focusing on the effects of these inhibitors on synovial fibroblasts – fibroblast-like synoviocytes.