PT  - JOURNAL ARTICLE
AU  - Rachel J Rowell
AU  - Quentin M Anstee
TI  - An overview of the genetics, mechanisms and management of NAFLD and ALD
AID  - 10.7861/clinmedicine.15-6-s77
DP  - 2015 Dec 01
TA  - Clinical Medicine
PG  - s77--s82
VI  - 15
IP  - Suppl 6
4099  - http://www.rcpjournals.org/content/15/Suppl_6/s77.short
4100  - http://www.rcpjournals.org/content/15/Suppl_6/s77.full
SO  - Clin Med2015 Dec 01; 15
AB  - Alcoholic liver disease (ALD) and, increasingly, non-alcoholic fatty liver disease (NAFLD) are common causes of advanced liver disease in many developed countries including the UK. Both diseases share parallel natural histories, progressing from steatosis, to steatohepatitis and fibrosis/cirrhosis; and are characterised by substantial interindividual variation in disease outcome. This article will provide an overview of disease mechanisms, genetic modifiers and management, focusing principally on NAFLD, while drawing parallels between the two conditions where appropriate.