RT Journal Article
SR Electronic
T1 An overview of the genetics, mechanisms and management of NAFLD and ALD
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP s77
OP s82
DO 10.7861/clinmedicine.15-6-s77
VO 15
IS Suppl 6
A1 Rachel J Rowell
A1 Quentin M Anstee
YR 2015
UL http://www.rcpjournals.org/content/15/Suppl_6/s77.abstract
AB Alcoholic liver disease (ALD) and, increasingly, non-alcoholic fatty liver disease (NAFLD) are common causes of advanced liver disease in many developed countries including the UK. Both diseases share parallel natural histories, progressing from steatosis, to steatohepatitis and fibrosis/cirrhosis; and are characterised by substantial interindividual variation in disease outcome. This article will provide an overview of disease mechanisms, genetic modifiers and management, focusing principally on NAFLD, while drawing parallels between the two conditions where appropriate.