PT - JOURNAL ARTICLE AU - Lorraine Watson AU - Amyn Lalji AU - Shankar Bodla AU - Ann Muls AU - H Jervoise N Andreyev AU - Clare Shaw TI - Management of bile acid malabsorption using low-fat dietary interventions: a useful strategy applicable to some patients with diarrhoea-predominant irritable bowel syndrome? AID - 10.7861/clinmedicine.15-6-536 DP - 2015 Dec 01 TA - Clinical Medicine PG - 536--540 VI - 15 IP - 6 4099 - http://www.rcpjournals.org/content/15/6/536.short 4100 - http://www.rcpjournals.org/content/15/6/536.full SO - Clin Med2015 Dec 01; 15 AB - This study evaluates the efficacy of low-fat dietary interventions in the management of gastrointestinal (GI) symptoms due to bile acid malabsorption. In total, 40 patients with GI symptoms and a 7-day 75selenium homocholic acid taurine (SeHCAT) scan result of <20%, were prospectively recruited and then advised regarding a low-fat dietary intervention. Before and after dietary intervention, patients rated their GI symptoms using a 10-point numerical scale, and recorded their intake in 7-day dietary diaries. After dietary intervention, the median scores for all GI symptoms decreased, with a significant reduction for urgency, bloating, lack of control, bowel frequency (p≥0.01). Mean dietary fat intake reduced to 42 g fat after intervention (p≥0.01). Low-fat dietary interventions in patients with a SeHCAT scan result of <20% leads to clinically important improvement in GI symptoms and should be widely used.