RT Journal Article
SR Electronic
T1 Management of bile acid malabsorption using low-fat dietary interventions: a useful strategy applicable to some patients with diarrhoea-predominant irritable bowel syndrome?
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 536
OP 540
DO 10.7861/clinmedicine.15-6-536
VO 15
IS 6
A1 Lorraine Watson
A1 Amyn Lalji
A1 Shankar Bodla
A1 Ann Muls
A1 H Jervoise N Andreyev
A1 Clare Shaw
YR 2015
UL http://www.rcpjournals.org/content/15/6/536.abstract
AB This study evaluates the efficacy of low-fat dietary interventions in the management of gastrointestinal (GI) symptoms due to bile acid malabsorption. In total, 40 patients with GI symptoms and a 7-day 75selenium homocholic acid taurine (SeHCAT) scan result of <20%, were prospectively recruited and then advised regarding a low-fat dietary intervention. Before and after dietary intervention, patients rated their GI symptoms using a 10-point numerical scale, and recorded their intake in 7-day dietary diaries. After dietary intervention, the median scores for all GI symptoms decreased, with a significant reduction for urgency, bloating, lack of control, bowel frequency (p≥0.01). Mean dietary fat intake reduced to 42 g fat after intervention (p≥0.01). Low-fat dietary interventions in patients with a SeHCAT scan result of <20% leads to clinically important improvement in GI symptoms and should be widely used.