RT Journal Article
SR Electronic
T1 Severe adverse drug reactions
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 79
OP 83
DO 10.7861/clinmedicine.16-1-79
VO 16
IS 1
A1 Ying Xin Teo
A1 Sarah Anne Walsh
YR 2016
UL http://www.rcpjournals.org/content/16/1/79.abstract
AB Severe cutaneous adverse reactions (SCARs) can present in a multitude of ways including Stevens–Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, and acute generalised exanthematous pustulosis. While the prognosis and therapy for these conditions may vary, it is crucial that the culprit drug is identified and withheld early as this can influence patient outcome. Mainstay of management is by supportive therapy. In all SCARs, long-term sequelae which may not be apparent initially can be debilitating and cause lasting impact on the quality of life of survivors.