TY - JOUR T1 - Severe adverse drug reactions JF - Clinical Medicine JO - Clin Med SP - 79 LP - 83 DO - 10.7861/clinmedicine.16-1-79 VL - 16 IS - 1 AU - Ying Xin Teo AU - Sarah Anne Walsh Y1 - 2016/02/01 UR - http://www.rcpjournals.org/content/16/1/79.abstract N2 - Severe cutaneous adverse reactions (SCARs) can present in a multitude of ways including Stevens–Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, and acute generalised exanthematous pustulosis. While the prognosis and therapy for these conditions may vary, it is crucial that the culprit drug is identified and withheld early as this can influence patient outcome. Mainstay of management is by supportive therapy. In all SCARs, long-term sequelae which may not be apparent initially can be debilitating and cause lasting impact on the quality of life of survivors. ER -