@article {Gilbert274, author = {Jackie Gilbert}, title = {Thyrotoxicosis {\textendash} investigation and management}, volume = {17}, number = {3}, pages = {274--277}, year = {2017}, doi = {10.7861/clinmedicine.17-3-274}, publisher = {Royal College of Physicians}, abstract = {Graves{\textquoteright} disease (GD) and toxic nodular (TN) goitre account for most cases of thyrotoxicosis associated with hyperthyroidism. Hyperthyroidism is confirmed with measurement of a suppressed serum thyrotropin concentration (TSH) and elevated free thyroid hormones. The three therapeutic options are antithyroid drugs, radioactive iodine and surgery. Thionamides achieve long-term remission in 35\% of cases. Many centres administer fixed doses of iodine-131; larger doses result in improved rates of cure at the cost of hypothyroidism. Surgery is usually considered for patients who have a large goitre, compressive symptoms or significant ophthalmopathy.}, issn = {1470-2118}, URL = {https://www.rcpjournals.org/content/17/3/274}, eprint = {https://www.rcpjournals.org/content/17/3/274.full.pdf}, journal = {Clinical Medicine} }