PT  - JOURNAL ARTICLE
AU  - Jackie Gilbert
TI  - Thyrotoxicosis – investigation and management
AID  - 10.7861/clinmedicine.17-3-274
DP  - 2017 Jun 01
TA  - Clinical Medicine
PG  - 274--277
VI  - 17
IP  - 3
4099  - http://www.rcpjournals.org/content/17/3/274.short
4100  - http://www.rcpjournals.org/content/17/3/274.full
SO  - Clin Med2017 Jun 01; 17
AB  - Graves’ disease (GD) and toxic nodular (TN) goitre account for most cases of thyrotoxicosis associated with hyperthyroidism. Hyperthyroidism is confirmed with measurement of a suppressed serum thyrotropin concentration (TSH) and elevated free thyroid hormones. The three therapeutic options are antithyroid drugs, radioactive iodine and surgery. Thionamides achieve long-term remission in 35% of cases. Many centres administer fixed doses of iodine-131; larger doses result in improved rates of cure at the cost of hypothyroidism. Surgery is usually considered for patients who have a large goitre, compressive symptoms or significant ophthalmopathy.