TY - JOUR T1 - Thyrotoxicosis – investigation and management JF - Clinical Medicine JO - Clin Med SP - 274 LP - 277 DO - 10.7861/clinmedicine.17-3-274 VL - 17 IS - 3 AU - Jackie Gilbert Y1 - 2017/06/01 UR - http://www.rcpjournals.org/content/17/3/274.abstract N2 - Graves’ disease (GD) and toxic nodular (TN) goitre account for most cases of thyrotoxicosis associated with hyperthyroidism. Hyperthyroidism is confirmed with measurement of a suppressed serum thyrotropin concentration (TSH) and elevated free thyroid hormones. The three therapeutic options are antithyroid drugs, radioactive iodine and surgery. Thionamides achieve long-term remission in 35% of cases. Many centres administer fixed doses of iodine-131; larger doses result in improved rates of cure at the cost of hypothyroidism. Surgery is usually considered for patients who have a large goitre, compressive symptoms or significant ophthalmopathy. ER -