RT Journal Article
SR Electronic
T1 Thyrotoxicosis – investigation and management
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 274
OP 277
DO 10.7861/clinmedicine.17-3-274
VO 17
IS 3
A1 Jackie Gilbert
YR 2017
UL http://www.rcpjournals.org/content/17/3/274.abstract
AB Graves’ disease (GD) and toxic nodular (TN) goitre account for most cases of thyrotoxicosis associated with hyperthyroidism. Hyperthyroidism is confirmed with measurement of a suppressed serum thyrotropin concentration (TSH) and elevated free thyroid hormones. The three therapeutic options are antithyroid drugs, radioactive iodine and surgery. Thionamides achieve long-term remission in 35% of cases. Many centres administer fixed doses of iodine-131; larger doses result in improved rates of cure at the cost of hypothyroidism. Surgery is usually considered for patients who have a large goitre, compressive symptoms or significant ophthalmopathy.