RT Journal Article SR Electronic T1 Rational prescribing: the principles of drug selection JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 459 OP 464 DO 10.7861/clinmedicine.16-5-459 VO 16 IS 5 A1 Simon RJ Maxwell YR 2016 UL http://www.rcpjournals.org/content/16/5/459.abstract AB Prescribing is the most important tool used by physicians to cure illness, relieve symptoms and prevent future disease. It is also a complex intellectual task that requires formulation of an appropriate treatment regimen from the many thousands available, taking into account the infinite variation in the patients they encounter. Unfortunately, the selection of a medicine and dosage regimen is sometimes suboptimal, leading to poor patient outcomes (eg treatment failure, avoidable adverse reactions). This article will highlight some of the common prescribing errors and will develop a rational approach that includes making a diagnosis, estimating prognosis, establishing the goals of therapy, selecting the most appropriate treatment and monitoring the effects of the treatment.