RT Journal Article SR Electronic T1 An extreme case of platypnoea-orthodeoxia syndrome JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 453 OP 454 DO 10.7861/clinmedicine.16-5-453 VO 16 IS 5 A1 Kevin O’Gallagher A1 Evelyn Chou A1 Swarna Jeyabraba A1 Aish Sinha A1 Daniel Robb A1 Jonathan Byrne YR 2016 UL http://www.rcpjournals.org/content/16/5/453.abstract AB An 80-year-old female presented with progressive breathlessness, worse on sitting or standing and relieved by lying flat. Subsequent investigations identified a patent foramen ovale (PFO) with right-to-left flow across the interatrial septum (IAS). A diagnosis of platypnoea orthodeoxia syndrome secondary to inter-atrial shunting was made. Technical features precluded a percutaneous PFO closure so an open surgical repair was performed with complete resolution of symptoms. We discuss the pathophysiology and management of platypnoea orthodeoxia syndrome.