PT - JOURNAL ARTICLE AU - Ravi Varma AU - Gary Campbell AU - Helen Baxendale TI - Lesson of the month 1: Autoinflammatory syndromes – an unusual cause of pyrexia of unknown origin AID - 10.7861/clinmedicine.16-5-488 DP - 2016 Oct 01 TA - Clinical Medicine PG - 488--490 VI - 16 IP - 5 4099 - http://www.rcpjournals.org/content/16/5/488.short 4100 - http://www.rcpjournals.org/content/16/5/488.full SO - Clin Med2016 Oct 01; 16 AB - Autoinflammatory diseases are disorders of innate immunity and are characterised by recurring and unprovoked episodes of inflammation. We present a case of episodic pyrexia, associated with a significant inflammatory response, in a young man in whom the cause had remained unexplained since infancy. He was eventually diagnosed with hyperimmunoglobulinaemia D syndrome (HIDS); one of the autoinflammatory syndromes.